Article
Assessing the genetic risk of nodular melanoma using a candidate gene approach.
The British journal of dermatology - 23 Jan 2024
Stark Mitchell S, Sturm Richard A, Pan Yan, Smit Darren J, Kommajosyula Varsha, Lee Katie J, Jagirdar Kasturee, McLean Catriona, Duffy David L, Soyer H Peter, Mar Victoria J
Abstract excerpt
BACKGROUND: Nodular melanoma (NM) is a challenge to diagnose early due to its rapid growth and more atypical clinical presentation, making it the largest contributor to melanoma mortality. OBJECTIVES: Our study aim was to perform a rare-variant allele (RVA) analysis of whole-exome sequencing of patients with NM and non-NM (minor allele frequency ≤ 1% non-Finnish European) for a set of 500 candidate genes...
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