Article
Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria.
PLoS genetics - 1 Sept 2023
Opi D Herbert, Ndila Carolyne M, Uyoga Sophie, Macharia Alex W, Fennell Clare, Ochola Lucy B, Nyutu Gideon, Siddondo Bethseba R, Ojal John, Shebe Mohammed, Awuondo Kennedy O, Mturi Neema, Peshu Norbert, Tsofa Benjamin, Band Gavin, Maitland Kathryn, Kwiatkowski Dominic P, Rockett Kirk A, Williams Thomas N, Rowe J Alexandra
Abstract excerpt
Blood group O is associated with protection against severe malaria and reduced size and stability of P. falciparum-host red blood cell (RBC) rosettes compared to non-O blood groups. Whether the non-O blood groups encoded by the specific ABO genotypes AO, BO, AA, BB and AB differ in their associations with severe malaria and rosetting is unknown. The A and B antigens are host RBC receptors for rosetting, hence we...
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