Sequencing 4.3 million mutations in wheat promoters to understand and modify gene expression.

doi:10.1073/pnas.2306494120

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Sequencing 4.3 million mutations in wheat promoters to understand and modify gene expression.

Proceedings of the National Academy of Sciences of the United States of America - 19 Sept 2023

Zhang Junli, Xiong Hongchun, Burguener Germán F, Vasquez-Gross Hans, Liu Qiujie, Debernardi Juan M, Akhunova Alina, Garland-Campbell Kimberly, Kianian Shahryar F, Brown-Guedira Gina, Pozniak Curtis, Faris Justin D, Akhunov Eduard, Dubcovsky Jorge

Abstract excerpt

Wheat is an important contributor to global food security, and further improvements are required to feed a growing human population. Functional genetics and genomics tools can help us to understand the function of different genes and to engineer beneficial changes. In this study, we used a promoter capture assay to sequence 2-kb regions upstream of all high-confidence annotated genes from 1,513 mutagenized plants...

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Sequencing 4.3 million mutations in wheat promoters to understand and modify gene expression.

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