Article
Research progress of the Fanconi anemia pathway and premature ovarian insufficiency†.
Biology of reproduction - 15 Nov 2023
Zhao Jingyu, Zhang Yixin, Li Wenbo, Yao Mengmeng, Liu Chuqi, Zhang Zihan, Wang Caiqin, Wang Xiaomei, Meng Kai
Abstract excerpt
The Fanconi anemia pathway is a key pathway involved in the repair of deoxyribonucleic acidinterstrand crosslinking damage, which chiefly includes the following four modules: lesion recognition, Fanconi anemia core complex recruitment, FANCD2-FANCI complex monoubiquitination, and downstream events (nucleolytic incision, translesion synthesis, and homologous recombination). Mutations or deletions of multiple...
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