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Article

Unveiling the SOD1-mediated ALS phenotype: insights from a comprehensive meta-analysis.

Journal of neurology - 1 Mar 2024

Domi Teuta, Schito Paride, Sferruzza Giacomo, Russo Tommaso, Pozzi Laura, Agosta Federica, Carrera Paola, Riva Nilo, Filippi Massimo, Quattrini Angelo, Falzone Yuri Matteo

Abstract excerpt

BACKGROUND AND OBJECTIVES: Amyotrophic lateral sclerosis associated with mutations in SOD1 (SOD1-ALS) might be susceptible to specific treatment. The aim of the study is to outline the clinical features of SOD1-ALS patients by comparing them to patients without ALS major gene variants and patients with variants in other major ALS genes. Defining SOD1-ALS phenotype may assist clinicians in identifying patients who...

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PMID: 37930481
DOI: 10.1007/s00415-023-12074-6

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