Article
Evaluation of the risk of diarrhea induced by epidermal growth factor receptor tyrosine kinase inhibitors with cultured intestinal stem cells originated from crypts in humans and monkeys.
Toxicology in vitro : an international journal published in association with BIBRA - 1 Dec 2023
Hashimoto Yoshiki, Maeda Kazuya, Shimomura Osamu, Miyazaki Yoshihiro, Hashimoto Shinji, Moriyama Akiko, Oda Tatsuya, Kusuhara Hiroyuki
Abstract excerpt
Severe diarrhea is a common side effect of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). We aimed to evaluate the risk of EGFR-TKI-induced diarrhea using spheroids of human and monkey crypt-derived intestinal stem cells. Intestinal spheroids exhibited higher toxic susceptibility to EGFR-TKIs than Caco-2 cells. As concentration of EGFR-TKIs increased, cellular ATP first decreased...
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