Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The microbiota conditions a gut milieu that selects for wild-type Salmonella Typhimurium virulence

31 Aug 2023

Abstract excerpt

Salmonella Typhimurium elicits gut inflammation by the costly expression of HilD-controlled virulence factors. This inflammation alleviates colonization resistance (CR) mediated by the microbiota and thereby promotes pathogen blooms. However, the inflamed gut-milieu can also select for hilD mutants, which cannot elicit or maintain inflammation, therefore causing a loss of the pathogen's virulence. This raises the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clostridium difficile and Clostridium perfringens research
Share to Gut microbiota and health
Share to Salmonella and Campylobacter epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37651408
DOI: 10.1371/journal.pbio.3002253

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The microbiota conditions a gut milieu that selects for wild-type Salmonella Typhimurium virulencePMID 37651408Read ↗

Establishing causality in Salmonella-microbiota-host interaction: The use of gnotobiotic mouse models and synthetic microbial communitiesSemantic proximity Read ↗

Mechanisms conferring multi-layered protection against intestinal Salmonella Typhimurium infectionSemantic proximity Read ↗

Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota.Semantic proximity Read ↗

Host microbiota can facilitate pathogen infectionSemantic proximity Read ↗

Granulocytes impose a tight bottleneck upon the gut luminal pathogen population during Salmonella typhimurium colitis.Semantic proximity Read ↗

The streptomycin mouse model for <i>Salmonella</i> diarrhea: functional analysis of the microbiota, the pathogen’s virulence factors, and the host’s mucosal immune responseSemantic proximity Read ↗

Host-Microbiota Interactions in the Pathogenesis of Antibiotic-Associated DiseasesSemantic proximity Read ↗

Host Transmission of <i>Salmonella enterica</i> Serovar Typhimurium Is Controlled by Virulence Factors and Indigenous Intestinal MicrobiotaSemantic proximity Read ↗

Gut microbiota within-host evolution enforces colonization resistance against enteric infectionSemantic proximity Read ↗

Evolution of <i>E. coli</i> in a mouse model of inflammatory bowel disease leads to a disease-specific bacterial genotype and trade-offs with clinical relevanceSemantic proximity Read ↗

Incomplete immunity in a natural animal-microbiota interaction selects for higher pathogen virulenceSemantic proximity Read ↗

Bacteriophages targeting protective commensals impair resistance against Salmonella Typhimurium infection in gnotobiotic miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.