Article
Genetic causes of sporadic and recurrent miscarriage.
Fertility and sterility - 1 Nov 2023
Melo Pedro, Dhillon-Smith Rima, Islam Md Asiful, Devall Adam, Coomarasamy Arri
Abstract excerpt
Approximately 80% of miscarriages happen within the first 12 weeks of gestation. More than half of early losses result from genetic defects, usually presenting as abnormal chromosome numbers or gene rearrangements in the embryo. However, the impact of genetics on pregnancy loss goes well beyond embryonic aneuploidy. For example, the use of big data has recently led to the discovery of specific gene mutations that...
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