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Article

Cell-Type Composition Affects Adipose Gene Expression Associations With Cardiometabolic Traits

30 Aug 2023

Abstract excerpt

Understanding differences in adipose gene expression between individuals with different levels of clinical traits may reveal the genes and mechanisms leading to cardiometabolic diseases. However, adipose is a heterogeneous tissue. To account for cell-type heterogeneity, we estimated cell-type proportions in 859 subcutaneous adipose tissue samples with bulk RNA sequencing (RNA-seq) using a reference single-nuclear...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 37647564
DOI: 10.2337/db23-0365

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