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Article

The Role of ONECUT1 Variants in Monogenic and Type 2 Diabetes Mellitus.

Diabetes - 1 Nov 2023

Russ-Silsby James, Patel Kashyap A, Laver Thomas W, Hawkes Gareth, Johnson Matthew B, Wakeling Matthew N, Patil Prashant P, Hattersley Andrew T, Flanagan Sarah E, Weedon Michael N, De Franco Elisa

Abstract excerpt

ONECUT1 (also known as HNF6) is a transcription factor involved in pancreatic development and β-cell function. Recently, biallelic variants in ONECUT1 were reported as a cause of neonatal diabetes mellitus (NDM) in two subjects, and missense monoallelic variants were associated with type 2 diabetes and possibly maturity-onset diabetes of the young (MODY). Here we examine the role of ONECUT1 variants in NDM, MODY,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Diabetes Mellitus, Type 2

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Share to Infant, Newborn, Diseases

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Source

Open in PubMed Open full text

Identifiers

PMID: 37639628
DOI: 10.2337/db23-0498
PMCID: PMC7619148

Genes

ONECUT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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