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Statistical methods to detect mother-father genetic interaction effects on risk of infertility: A genome-wide approach.

Genetic epidemiology - 1 Oct 2023

Skodvin Siri N, Gjessing Håkon K, Jugessur Astanand, Romanowska Julia, Page Christian M, Corfield Elizabeth C, Lee Yunsung, Håberg Siri E, Gjerdevik Miriam

Abstract excerpt

Infertility is a heterogeneous phenotype, and for many couples, the causes of fertility problems remain unknown. One understudied hypothesis is that allelic interactions between the genotypes of the two parents may influence the risk of infertility. Our aim was, therefore, to investigate how allelic interactions can be modeled using parental genotype data linked to 15,789 pregnancies selected from the Norwegian...

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PMID: 37638522
DOI: 10.1002/gepi.22534

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DNAH17

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