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The small non-coding RNA B11 regulates multiple facets of Mycobacterium abscessus virulence

21 Aug 2023

Abstract excerpt

Mycobacterium abscessus causes severe disease in patients with cystic fibrosis. Little is known in M. abscessus about the roles of small regulatory RNAs (sRNA) in gene regulation. We show that the sRNA B11 controls gene expression and virulence-associated phenotypes in this pathogen. B11 deletion from the smooth strain ATCC_19977 produced a rough strain, increased pro-inflammatory signaling and virulence in...

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PMID: 37603560
DOI: 10.1371/journal.ppat.1011575

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