Article
Blood Plasma Small Non-Coding RNAs as Diagnostic Molecules for the Progesterone-Receptor-Negative Phenotype of Serous Ovarian Tumors.
International journal of molecular sciences - 30 Jul 2023
Timofeeva Angelika V, Fedorov Ivan S, Asaturova Aleksandra V, Sannikova Maya V, Tregubova Anna V, Mayboroda Oleg A, Khabas Grigory N, Frankevich Vladimir E, Sukhikh Gennady T
Abstract excerpt
The expression level of the progesterone receptor (PGR) plays a crucial role in determining the biological characteristics of serous ovarian carcinoma. Low PGR expression is associated with chemoresistance and a poorer outcome. In this study, our objective was to explore the relationship between tumor progesterone receptor levels and RNA profiles (miRNAs, piwiRNAs, and mRNAs) to understand their biological...
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