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Dynamics of intestinal and intratumoral microbiome signatures in genetically engineered mice and human pancreatic ductal adenocarcinoma

31 Jul 2023

Abstract excerpt

BACKGROUND: Emerging evidence has recently revealed a prominent role of the microbiome in pancreatic ductal adenocarcinoma (PDAC). However, while most observations were made in patients, mouse models still require a precise characterization of their disease-related microbiome to employ them for mechanistic and interventional preclinical studies. METHODS: ;Pdx-1-Cre (KPC) and control (CTRL) mice, Oxford Nanopore...

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PMID: 37541802
DOI: 10.1016/j.pan.2023.07.008

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