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Article

Intestinal microbiota enhances pancreatic carcinogenesis in preclinical models

25 May 2018

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the United States yet data are scant regarding host factors influencing pancreatic carcinogenesis. Increasing evidence support the role of the host microbiota in carcinogenesis but its role in PDAC is not well established. Herein, we report that antibiotic-mediated microbial depletion of KrasG12D/PTENlox/+ mice showed a...

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PMID: 29846515
DOI: 10.1093/carcin/bgy073

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