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Bifidobacterium adolescentis orchestrates CD143 + cancer‐associated fibroblasts to suppress colorectal tumorigenesis by Wnt signaling‐regulated GAS1

2 Aug 2023

Abstract excerpt

Abstract Background The interplay between gut microbiota and tumor microenvironment (TME) in the pathogenesis of colorectal cancer (CRC) is not well explored. Here, we elucidated the functional role of Bifidobacterium adolescentis ( B.a ) on CRC and investigated its possible mechanism on the manipulation of cancer‐associated fibroblasts (CAFs) in CRC. Methods Different CRC animal models and various cell line...

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PMID: 37533188
DOI: 10.1002/cac2.12469

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