Article
Direct inference and control of genetic population structure from RNA sequencing data.
Communications biology - 2 Aug 2023
Fachrul Muhamad, Karkey Abhilasha, Shakya Mila, Judd Louise M, Harshegyi Taylor, Sim Kar Seng, Tonks Susan, Dongol Sabina, Shrestha Rajendra, Salim Agus, Baker Stephen, Pollard Andrew J, Khor Chiea Chuen, Dolecek Christiane, Basnyat Buddha, Dunstan Sarah J, Holt Kathryn E, Inouye Michael
Abstract excerpt
RNAseq data can be used to infer genetic variants, yet its use for estimating genetic population structure remains underexplored. Here, we construct a freely available computational tool (RGStraP) to estimate RNAseq-based genetic principal components (RG-PCs) and assess whether RG-PCs can be used to control for population structure in gene expression analyses. Using whole blood samples from understudied Nepalese...
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