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Article

Personalized medicine with germline pathogenic variants: Importance of population- and region-wide evidence.

Cancer science - 1 Oct 2023

Usui Yoshiaki, Momozawa Yukihide

Abstract excerpt

Rare germline pathogenic variants in cancer-predisposing genes have a high impact and potential for clinical utility. In the last 30 years, based on evidence of cancer risk associated with germline pathogenic variants, several measures have been suggested for personalized medicine, including the development of novel treatments, treatment stratification, risk reduction by surgical measures, chemoprevention,...

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Identifiers

PMID: 37530079
DOI: 10.1111/cas.15922
PMCID: PMC10551596

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