Article
Association of Molecular Profiles and Mutational Status With Distinct Histological Lung Adenocarcinoma Subtypes. An Analysis of the LACE-Bio Data.
Clinical lung cancer - 1 Sept 2023
Ashok Kumar Prashanth, Karimi Maryam, Basnet Alina, Seymour Lesley, Kratzke Robert, Brambilla Elizabeth, Le-Chevalier Thierry, Soria Jean-Charles, Olaussen Ken André, Devarakonda Siddhartha, Govindan Ramaswamy, Tsao Ming-Sound, Shepherd Frances A, Michiels Stefan, Graziano Stephen
Abstract excerpt
BACKGROUND: Adjuvant chemotherapy (AC) is indicated for stage II and stage III lung adenocarcinomas (ADC). Using the LACE Bio II database, we analyzed the distribution of various mutations across the subtypes of ADCs and studied the prognostic and predictive roles of PD-L1, TMB, and Tumor Infiltrating Lymphocytes (TILs). MATERIALS AND METHODS: Clinical and genomic data from the LACE Bio II data were extracted....
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