A human leukocyte antigen imputation study uncovers possible genetic interplay between gut inflammatory processes and autism spectrum disorders.

doi:10.1038/s41398-023-02550-y

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A human leukocyte antigen imputation study uncovers possible genetic interplay between gut inflammatory processes and autism spectrum disorders.

Translational psychiatry - 6 Jul 2023

Lombardi Laura, Le Clerc Sigrid, Wu Ching-Lien, Bouassida Jihène, Boukouaci Wahid, Sugusabesan Sobika, Richard Jean-Romain, Lajnef Mohamed, Tison Maxime, Le Corvoisier Philippe, Barau Caroline, Banaschewski Tobias, Holt Rosemary, Durston Sarah, Persico Antonio M, Oakley Bethany, Loth Eva, Buitelaar Jan, Murphy Declan, Leboyer Marion, Zagury Jean-François, Tamouza Ryad

Abstract excerpt

Autism spectrum disorders (ASD) are neurodevelopmental conditions that are for subsets of individuals, underpinned by dysregulated immune processes, including inflammation, autoimmunity, and dysbiosis. Consequently, the major histocompatibility complex (MHC)-hosted human leukocyte antigen (HLA) has been implicated in ASD risk, although seldom investigated. By utilizing a GWAS performed by the EU-AIMS consortium...

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PMID: 37407551
DOI: 10.1038/s41398-023-02550-y
PMCID: PMC10322870

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