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Lung Function in Patients with Cystic Fibrosis before and during CFTR-Modulator Therapy Using 3D Ultrashort Echo Time MRI.

Radiology - 1 Jul 2023

Heidenreich Julius Frederik, Kuhl Philipp Josef, Grunz Jan-Peter, Hendel Robin, Metz Corona, Weng Andreas Max, Benkert Thomas, Hebestreit Helge, Bley Thorsten Alexander, Köstler Herbert, Veldhoen Simon

Abstract excerpt

Background The triple combination of the cystic fibrosis transmembrane regulator (CFTR) modulators elexacaftor, tezacaftor, and ivacaftor (hereafter, elexacaftor/tezacaftor/ivacaftor) has a positive effect on lung function in patients with cystic fibrosis (CF). Purpose To compare three-dimensional (3D) ultrashort echo time (UTE) MRI functional lung data to common functional lung parameters in assessing lung...

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PMID: 37404154
DOI: 10.1148/radiol.230084

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