Article
Structural changes in lung morphology detected by MRI after modulating therapy with elexacaftor/tezacaftor/ivacaftor in adolescent and adult patients with cystic fibrosis.
Respiratory medicine - 1 Sept 2023
Fainardi Valentina, Skenderaj Kaltra, Ciuni Andrea, Milanese Gianluca, Deolmi Michela, Longo Francesco, Spaggiari Cinzia, Sverzellati Nicola, Esposito Susanna, Pisi Giovanna
Abstract excerpt
INTRODUCTION: Elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) improves CFTR function in cystic fibrosis (CF) patients homozygous or heterozygous for F508del mutation. The aim of the study was to evaluate the response to ELX/TEZ/IVA treatment both clinically and morphologically in terms of bronchiectasis, bronchial wall thickening, mucus plugging, abscess and consolidations. METHODS: We retrospectively collected...
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