Article
Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7.
Molecular cancer - 1 Jul 2023
Li Kai, Peng Zi-Yang, Wang Rui, Li Xiang, Du Ning, Liu Da-Peng, Zhang Jia, Zhang Yun-Feng, Ma Lei, Sun Ye, Tang Shou-Ching, Ren Hong, Yang Yi-Ping, Sun Xin
Abstract excerpt
BACKGROUND: Tyrosine kinase inhibitors (TKIs) that specifically target mutational points in the EGFR gene have significantly reduced suffering and provided greater relief to patients with lung adenocarcinoma (LUAD). The third-generation EGFR-TKI, Osimertinib, has been successfully employed in clinical treatments to overcome resistance to both original and acquired T790M and L858R mutational points. Nevertheless,...
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