Article
Parents' expectations, preferences, and recall of germline findings in a childhood cancer precision medicine trial.
Cancer - 15 Nov 2023
McGill Brittany C, Wakefield Claire E, Tucker Katherine M, Daly Rebecca A, Donoghoe Mark W, Vetsch Janine, Warby Meera, Fuentes-Bolanos Noemi A, Barlow-Stewart Kristine, Kirk Judy, Courtney Eliza, O'Brien Tracey A, Marshall Glenn M, Pinese Mark, Cowley Mark J, Tyrrell Vanessa, Deyell Rebecca J, Ziegler David S, Hetherington Kate
Abstract excerpt
BACKGROUND: Germline genome sequencing in childhood cancer precision medicine trials may reveal pathogenic or likely pathogenic variants in cancer predisposition genes in more than 10% of children. These findings can have implications for diagnosis, treatment, and the child's and family's future cancer risk. Understanding parents' perspectives of germline genome sequencing is critical to successful clinical...
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