Article
Induction of Anxiety-Like Phenotypes by Knockdown of Cannabinoid Type-1 Receptors in the Amygdala of Marmosets.
Neuroscience bulletin - 1 Nov 2023
Zhu Lin, Zheng Di, Li Rui, Shen Chen-Jie, Cai Ruolan, Lyu Chenfei, Tang Binliang, Sun Hao, Wang Xiaohui, Ding Yu, Xu Bin, Jia Guoqiang, Li Xinjian, Gao Lixia, Li Xiao-Ming
Abstract excerpt
The amygdala is an important hub for regulating emotions and is involved in the pathophysiology of many mental diseases, such as depression and anxiety. Meanwhile, the endocannabinoid system plays a crucial role in regulating emotions and mainly functions through the cannabinoid type-1 receptor (CB1R), which is strongly expressed in the amygdala of non-human primates (NHPs). However, it remains largely unknown...
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