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Article

Hypertrophic cardiomyopathy in purpose-bred cats with the A31P mutation in cardiac myosin binding protein-C.

Scientific reports - 26 Jun 2023

Stern Joshua A, Rivas Victor N, Kaplan Joanna L, Ueda Yu, Oldach Maureen S, Ontiveros Eric S, Kooiker Kristina B, van Dijk Sabine J, Harris Samantha P

Abstract excerpt

We sought to establish a large animal model of inherited hypertrophic cardiomyopathy (HCM) with sufficient disease severity and early penetrance for identification of novel therapeutic strategies. HCM is the most common inherited cardiac disorder affecting 1 in 250-500 people, yet few therapies for its treatment or prevention are available. A research colony of purpose-bred cats carrying the A31P mutation in...

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Share to Cardiac Myosins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37365215
DOI: 10.1038/s41598-023-36932-5
PMCID: PMC10293195

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