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Impact of peripheral mitochondrial DNA level on immune response after COVID-19 vaccination

10 Jun 2023

Abstract excerpt

The efficacy of vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the elderly is partially hindered by immunosenescence, resulting from decreased mtDNA levels. This study evaluated the correlation between mtDNA levels in peripheral leukocytes and immune response to the SARS-CoV-2 vaccine. Two hundred ten participants (median age 79.5 years), including 83 frail...

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PMID: 37351502
DOI: 10.1016/j.isci.2023.107094

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