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Article

ELF3 suppresses gallbladder cancer development through downregulation of the EREG / EGFR / mTOR complex 1 signalling pathway

22 Jun 2023

Abstract excerpt

Abstract The prognosis of gallbladder cancer (GBC) remains poor, and a better understanding of GBC molecular mechanisms is important. Genome sequencing of human GBC has demonstrated that loss‐of‐function mutations of E74‐like ETS transcription factor 3 (ELF3) are frequently observed, with ELF3 considered to be a tumour suppressor in GBC. To clarify the underlying molecular mechanisms by which ELF3 suppresses GBC...

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PMID: 37345534
DOI: 10.1002/path.6144

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