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Article

A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer

15 Jun 2023

Abstract excerpt

Intratumor heterogeneity associates with poor patient outcome. Stromal stiffening also accompanies cancer. Whether cancers demonstrate stiffness heterogeneity, and if this is linked to tumor cell heterogeneity remains unclear. We developed a method to measure the stiffness heterogeneity in human breast tumors that quantifies the stromal stiffness each cell experiences and permits visual registration with...

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PMID: 37322009
DOI: 10.1038/s41467-023-39085-1

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