Article
An atypical expression of core α-Dystroglycan and Laminin-α2 in skin fibroblasts of patients with congenital muscular dystrophies.
Molecular biology reports - 1 Aug 2023
Sabry Sahar, Issa Mahmoud Y, Abdel-Hamid Mohamed S, Eissa Noura R, Abdel-Ghafar Sherif F, Ibrahim Mona M, Zaki Maha S
Abstract excerpt
BACKGROUND: Congenital muscular dystrophies (CMDs) result from genetically inherited defects in the biosynthesis and/or the posttranslational modification (glycosylation) of laminin-α2 and α-dystroglycan (α-DG), respectively. The interaction between both proteins is responsible for the stability and integrity of the muscle cell. We aimed to study the expression profiles of both proteins in two classes of CMDs....
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