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Mesenchymal stem cell-derived microRNAs: Friends or foes of tumor cells?

Histology and histopathology - 1 Dec 2023

Harrell Carl Randall, Djonov Valentin, Volarevic Vladislav

Abstract excerpt

Mesenchymal stem cell (MSC)-dependent biological effects in the tumor microenvironment mainly rely on the activity of MSC-sourced microRNAs (MSC-miRNAs) which modulate protein synthesis in target tumor cells, endothelial cells and tumor-infiltrated immune cells, regulating their phenotype and function. Several MSC-sourced miRNAs (miR-221, miR-23b, miR-21-5p, miR-222/223, miR-15a miR-424, miR-30b, miR-30c) possess...

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PMID: 37306386
DOI: 10.14670/HH-18-633

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