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Article

Evaluating the distinct pleiotropic effects of omega-3 fatty acids on type 2 diabetes mellitus: a mendelian randomization study.

Journal of translational medicine - 7 Jun 2023

Hu Chunyan, Zhou Yulin, Wu Xueyan, Jia Xiaojing, Zhu Yuanyue, Zheng Ruizhi, Wang Shuangyuan, Lin Lin, Qi Hongyan, Lin Hong, Li Mian, Wang Tiange, Zhao Zhiyun, Xu Min, Xu Yu, Chen Yuhong, Ning Guang, Borges Maria-Carolina, Wang Weiqing, Zheng Jie, Bi Yufang, Lu Jieli

Abstract excerpt

BACKGROUND: Observational studies and conventional Mendelian randomization (MR) studies showed inconclusive evidence to support the association between omega-3 fatty acids and type 2 diabetes. We aim to evaluate the causal effect of omega-3 fatty acids on type 2 diabetes mellitus (T2DM), and the distinct intermediate phenotypes linking the two. METHODS: Two-sample MR was performed using genetic instruments...

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Share to Diabetes Mellitus, Type 2
Share to Fatty Acids, Omega-3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 37286992
DOI: 10.1186/s12967-023-04202-7
PMCID: PMC10249205

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