Article
Frequent Emergence of Resistance Mutations Following Complex Intra-Host Genomic Dynamics in SARS-CoV-2 Patients Receiving Sotrovimab.
Antimicrobial agents and chemotherapy - 18 Jul 2023
Palomino-Cabrera Rosalía, Tejerina Francisco, Molero-Salinas Andrea, Ferris María, Veintimilla Cristina, Catalán Pilar, Rodríguez Macias Gabriela, Alonso Roberto, Muñoz Patricia, García de Viedma Darío, Pérez-Lago Laura
Abstract excerpt
The emergence of the Omicron variant of SARS-CoV-2 represented a challenge to the treatment of COVID-19 using monoclonal antibodies. Only Sotrovimab maintained partial activity, allowing it to be used in high-risk patients infected with the Omicron variant. However, reports of resistance mutations to Sotrovimab demand efforts to better understand the intra-patient emergence of Sotrovimab resistance. A...
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