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Novel emm4 lineage associated with an upsurge in invasive group A streptococcal disease in the Netherlands, 2022

1 Jun 2023

Abstract excerpt

Invasive group A streptococcal (iGAS) disease cases increased in the first half of 2022 in the Netherlands, with a remarkably high proportion of emm 4 isolates. Whole-genome sequence analysis of 66 emm 4 isolates, 40 isolates from the pre-coronavirus disease 2019 (COVID-19) pandemic period 2009–2019 and 26 contemporary isolates from 2022, identified a novel Streptococcus pyogenes lineage (M4 NL22 ), which...

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PMID: 37261428
DOI: 10.1099/mgen.0.001026

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