Analysis and comparisons of gene expression changes in patient- derived neurons from ROHHAD, CCHS, and PWS

Abstract excerpt

Background Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) syndrome is an ultra-rare neurocristopathy with no known genetic or environmental etiology. Rapid-onset obesity over a 3–12 month period with onset between ages 1.5–7 years of age is followed by an unfolding constellation of symptoms including severe hypoventilation that can lead to...

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