Article
Generation and characterization of PBMCs-derived human induced pluripotent stem cell (iPSC) line SDQLCHi051-A from an autism spectrum disorder patient with compound CHD8 gene mutations.
Stem cell research - 1 Jun 2023
Fan Yuxuan, Li Yue, Yang Xiaomeng, Zhang Haiyan, Wang Bin, Guan Jingyun, Gao Jianen, Ma Xu, Liu Yi
Abstract excerpt
CHD8 mutation is a case of genetic related autism spectrum disorder(ASD), In our research, We describe here the derivation of the iPSC line SDQLCHi051-A from a patient with autism spectrum disorder (ASD) due to two heterozygote mutations (c.6728G > A and c.3876 T > G) in the CHD8 gene. The resulting iPSC line has typical iPSCs characteristics, including pluripotency and trilineage differentiation hallmarks.
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