Article
Evolution of Mycobacterium abscessus in the human lung: Cumulative mutations and genomic rearrangement of porin genes in patient isolates.
Virulence - 1 Dec 2023
Shallom Shamira J, Tettelin Hervé, Chandrasekaran Prabha, Park In Kwon, Agrawal Sonia, Arora Kriti, Sadzewicz Lisa, Milstone Aaron M, Aitken Moira L, Brown-Elliott Barbara A, Wallace Richard J, Sampaio Elizabeth P, Niederweis Michael, Olivier Kenneth N, Holland Steven M, Zelazny Adrian M
Abstract excerpt
BACKGROUND: Mycobacterium abscessus subspecies massiliense (M. massiliense) is increasingly recognized as an emerging bacterial pathogen, particularly in cystic fibrosis (CF) patients and CF centres' respiratory outbreaks. We characterized genomic and phenotypic changes in 15 serial isolates from two CF patients (1S and 2B) with chronic pulmonary M. massiliense infection leading to death, as well as four isolates...
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