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Candida albicans selection for human commensalism results in substantial within-host diversity without decreasing fitness for invasive disease

19 May 2023

Abstract excerpt

Candida albicans is a frequent colonizer of human mucosal surfaces as well as an opportunistic pathogen. C. albicans is remarkably versatile in its ability to colonize diverse host sites with differences in oxygen and nutrient availability, pH, immune responses, and resident microbes, among other cues. It is unclear how the genetic background of a commensal colonizing population can influence the shift to...

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PMID: 37205709
DOI: 10.1371/journal.pbio.3001822

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