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Article

Air pollution, EGFR mutation, and cancer initiation.

Cell reports. Medicine - 16 May 2023

Han Si-Chong, Wang Gui-Zhen, Zhou Guang-Biao

Abstract excerpt

Swanton et al.1 find that PM2.5 exposure is associated with EGFR/KRAS-driven lung cancer incidence. PM2.5 increases EGFR pre-mutated alveolar type II cell progenitor function and tumorigenic activity through interstitial macrophage-secreted IL-1β, providing potential prevention approaches to inhibit cancer initiation.

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Identifiers

PMID: 37196632
DOI: 10.1016/j.xcrm.2023.101046
PMCID: PMC10213952

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