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Article

Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens.

BMC biology - 11 May 2023

Mixão Verónica, Nunez-Rodriguez Juan Carlos, Del Olmo Valentina, Ksiezopolska Ewa, Saus Ester, Boekhout Teun, Gacser Attila, Gabaldón Toni

Abstract excerpt

BACKGROUND: Hybrids are chimeric organisms with highly plastic heterozygous genomes that may confer unique traits enabling the adaptation to new environments. However, most evolutionary theory frameworks predict that the high levels of genetic heterozygosity present in hybrids from divergent parents are likely to result in numerous deleterious epistatic interactions. Under this scenario, selection is expected to...

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PMID: 37170256
DOI: 10.1186/s12915-023-01608-z
PMCID: PMC10173528

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