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The heterogeneity of Parkinson’s disease

11 May 2023

Abstract excerpt

The heterogeneity of Parkinson's disease (PD), i.e. the various clinical phenotypes, pathological findings, genetic predispositions and probably also the various implicated pathophysiological pathways pose a major challenge for future research projects and therapeutic trail design. We outline several pathophysiological concepts, pathways and mechanisms, including the presumed roles of α-synuclein misfolding and...

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PMID: 37169935
DOI: 10.1007/s00702-023-02635-4

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