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Identification of heat shock protein family A member 5 (HSPA5) targets involved in nonalcoholic fatty liver disease

8 May 2023

Abstract excerpt

Heat shock protein family A (Hsp70) member 5 (HSPA5) is an endoplasmic reticulum chaperone, which regulates cell metabolism, particularly lipid metabolism. While HSPA5's role in regulating cell function is well described, HSPA5 binding to RNA and its biological function in nonalcoholic fatty liver disease (NAFLD) is still lacking. In the present study, the ability of HSPA5 to modulate alternative splicing (AS) of...

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PMID: 37156995
DOI: 10.1038/s41435-023-00205-y

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