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A novel homozygous mutation in the NLRP2 gene causes early embryonic arrest.

Journal of assisted reproduction and genetics - 1 Dec 2024

Chai Menghan, Wen Xingxing, Yang Dandan, Zhang Qiannan, Yang Ni, Cao Yunxia, Zhang Zhiguo, Li Lin, Chen Beili

Abstract excerpt

PURPOSE: Successful reproduction in humans requires maturation and fertilization of gametes as well as early embryonic development. Any deviation from these processes leads to infertility. Early embryonic arrest (EEA) is common in female infertility and is primarily attributed to genetic factors. Mutations in the NLRP2 gene have been identified as the causative factors for EEA. In the present study, a novel...

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PMID: 39585517
DOI: 10.1007/s10815-024-03279-3

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