Article
Genetic events associated with venetoclax resistance in CLL identified by whole-exome sequencing of patient samples
5 May 2023
Abstract excerpt
Although BCL2 mutations are reported as later occurring events leading to venetoclax resistance, many other mechanisms of progression have been reported though remain poorly understood. Here, we analyze longitudinal tumor samples from 11 patients with disease progression while receiving venetoclax to characterize the clonal evolution of resistance. All patients tested showed increased in vitro resistance to...
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