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Article

Bi-allelic variants inASTLcause abnormal fertilization or oocyte maturation defects

3 May 2023

Abstract excerpt

Fertilization is a fundamental process of development, and the blocking mechanisms act at the zona pellucida (ZP) and plasma membrane of the egg to prevent any additional sperm from binding, permeating and fusing after fertilization. In clinical practice, some couples undergoing recurrent IVF failures that mature oocytes had abnormal fertilization for unknown reason. Ovastacin encoded by ASTL cleave the ZP...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37133443
DOI: 10.1093/hmg/ddad070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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