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Single-cell metabolic fingerprints discover a cluster of circulating tumor cells with distinct metastatic potential

29 Apr 2023

Abstract excerpt

Circulating tumor cells (CTCs) are recognized as direct seeds of metastasis. However, CTC count may not be the "best" indicator of metastatic risk because their heterogeneity is generally neglected. In this study, we develop a molecular typing system to predict colorectal cancer metastasis potential based on the metabolic fingerprints of single CTCs. After identification of the metabolites potentially related to...

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PMID: 37120634
DOI: 10.1038/s41467-023-38009-3

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