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Article

Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs.

Science (New York, N.Y.) - 28 Apr 2023

Moon Katherine L, Huson Heather J, Morrill Kathleen, Wang Ming-Shan, Li Xue, Srikanth Krishnamoorthy, Lindblad-Toh Kerstin, Svenson Gavin J, Karlsson Elinor K, Shapiro Beth

Abstract excerpt

We reconstruct the phenotype of Balto, the heroic sled dog renowned for transporting diphtheria antitoxin to Nome, Alaska, in 1925, using evolutionary constraint estimates from the Zoonomia alignment of 240 mammals and 682 genomes from dogs and wolves of the 21st century. Balto shares just part of his diverse ancestry with the eponymous Siberian husky breed. Balto's genotype predicts a combination of coat...

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PMID: 37104591
DOI: 10.1126/science.abn5887
PMCID: PMC10184777

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