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Article

Sperm-borne microRNA-34c is required for the first cleavage division in mouse

27 Dec 2011

Abstract excerpt

In mammals, the sperm deliver mRNA of unknown function into the oocytes during fertilization. The role of sperm microRNAs (miRNAs) in preimplantation development is unknown. miRNA profiling identified six miRNAs expressed in the sperm and the zygotes but not in the oocytes or preimplantation embryos. Sperm contained both the precursor and the mature form of one of these miRNAs, miR-34c. The absence of an...

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PMID: 22203953
DOI: 10.1073/pnas.1110368109

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