Tackling the Pangenome Dilemma Requires the Concerted Analysis of Multiple Population Genetic Processes.

Abstract excerpt

The pangenome is the set of all genes present in a prokaryotic population. Most pangenomes contain many accessory genes of low and intermediate frequencies. Different population genetics processes contribute to the shape of these pangenomes, namely selection and fitness-independent processes such as gene transfer, gene loss, and migration. However, their relative importance is unknown and highly debated. Here, we...

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