Article
First reports of primary ciliary dyskinesia caused by a shared DNAH11 allele in Canadian Inuit.
Pediatric pulmonology - 1 Jul 2023
Hunter-Schouela Julia, Geraghty Michael T, Hegele Robert A, Dyment David A, St Pierre David, Richer Julie, Sheffield Holden, Zariwala Maimoona A, Knowles Michael R, Lehman Anna, Dell Sharon, Shapiro Adam J, Kovesi Thomas A
Abstract excerpt
BACKGROUND: Primary ciliary dyskinesia (PCD) is typically an autosomal recessive disease characterized by recurrent infections of the lower respiratory tract, frequent and severe otitis media, chronic rhinosinusitis, neonatal respiratory distress, and organ laterality defects. While severe lower respiratory tract infections and bronchiectasis are common in Inuit, PCD has not been recognized in this population....
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